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Rams vs. Bills prediction, odds: Matthew Stafford, Josh Allen clash in Week 5 'MNF' matchup

Here's how to watch Rams vs. Bills, along with the latest odds, key matchups and our Week 5 'Monday Night Football' prediction In the Week 5 edition of "Monday Night Football," the Los Angeles Rams host the Buffalo Bills. The Rams are coming off a too-close-for-comfort win over the Philadelphia Eagles, having improved to 2-2 on in the process. They have not quite been the super team many expected, though injuries have played their part. They have a chance to get above.500 if they can capture a win against the Bills on Monday night. The Bills, meanwhile, are coming off their first loss of the season, having dropped a dispiriting game against the division rival New England Patriots. The Bills had started 3-0 behind a pair of explosive offensive performances in Weeks 1 and 2 and then a comeback victory despite turning the ball over five times in Week 3. Their defense hasn't been up to snuff, and the Rams present a tremendous challenge. Will the Rams leave the stadium with a winning record, or will the Bills bounce back from last week's defeat? We'll find out soon enough. Before we break down the matchup, here's a look at how you can watch the game.

By Jared DubinOctober 13, 2026CBS Sports
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This Monday Night Football clash features two high-powered offenses led by veteran stars. Analysts are closely watching how each team's defensive schemes attempt to contain these prolific passers.

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